Lung Tumor Treatment Clinical Data

• Stereotactic body radiotherapy using real-time tumor tracking in octogenarians with non-small cell lung cancer. van der Voort van Zyp et al. 2010. Rotterdam researchers show that CyberKnife radiosurgery can be an effective treatment approach, with low rates of toxicity, for elderly patients with non-small cell lung cancer.
• Quality of life after stereotactic radiotherapy for stage I non-small-cell lung cancer. van der Voort van Zyp et al. 2010. Researchers from Rotterdam, The Netherlands, report on quality of life of 39 lung cancer patients in the first year after treatment with the CyberKnife System. In addition to a high tumor control rate and acceptable overall survival, the researchers observed no deterioration in global health status and respiratory symptoms, and a significant improvement in emotional functioning.
• Radical CyberKnife radiosurgery with tumor tracking: an effective treatment for inoperable small peripheral stage I non-small cell lung cancer. Collins et al. 2009. Georgetown researchers treated 20 patients with inoperable clinical stage I NSCLC with the CyberKnife System, delivering doses of 42-60 Gy in three equal fractions. At a median follow-up of 25 months for surviving patients, Kaplan-Meier overall survival at two years was 87%.
• Stereotactic radiotherapy with real-time tumor tracking for non-small cell lung cancer: Clinical outcome. van der Voort van Zyp et al., 2009. Clinicians from Rotterdam, the Netherlands, used the CyberKnife System to treat 70 surgically or medically inoperable patients with peripheral Stage I NSCLC with 45-60 Gy in 3 fractions. Authors report overall low toxicity and local tumor control at 2 years of 98% in the high-dose (60 Gy) patients.
• Fractionated stereotactic body radiation therapy in the treatment of primary, recurrent, and metastatic lung tumors: the role of positron emission tomography/computed tomography-based treatment planning. Coon et al. 2008. University of Pittsburgh researchers treated a variety of patients with primary lung cancer, metastatic lung tumors, or recurrent cancer. Using the CyberKnife System they delivered 3 fractions of 20 Gy and concluded it was an effective treatment for patients with medically inoperable recurrent or metastatic lung cancer.
• CyberKnife radiosurgery for stage I lung cancer: results at 36 months. Brown et al. 2007. Miami researchers show that image-guided robotic stereotactic radiosurgery of lung tumors with the CyberKnife System in medically inoperable patients with early non-small-cell lung cancer (NSCLC) achieves excellent local disease control with limited toxicity to surrounding tissues and, in many cases, might be curative for patients for whom surgery is not an option.
• Radical stereotactic radiosurgery with real-time tumor motion tracking in the treatment of small peripheral lung tumors. Collins et al. 2007. Georgetown researchers used the CyberKnife System to deliver 45-60 Gy in 3 fractions to small tumors (including some metastatic tumors) in the outer lung, resulting in 83% local control and 84% overall survival at 12 months.